J exp med

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Potential mechanisms driving obesity-related inflammation, primarily in adipose tissue and other metabolic organs and implications of circulatory inflammatory factors on various metabolic and regulatory organs. Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. WJEM accepts both solicited and unsolicited manuscripts. Articles published in WJEM are high-quality, clinical and basic, influential research articles by established academic authors as well as new researchers. The paramount objective of WJEM is to showcase and promote distinguished research in the field of experimental medicine, to help advance development of this field. Advanced Search. Risk factors for hydroxychloroquine-induced arrhythmia.

J exp med

Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. The journal has no single editor-in-chief , but thirteen academic editors. Welch , the school's founder and also the first president of the Board of Scientific Directors of the Rockefeller Institute since renamed Rockefeller University. From its inception, Welch edited the journal by himself—even editing manuscripts while attending baseball games. By March , the editorial burden became too great for Welch, who stopped publishing papers and began stockpiling manuscripts and unanswered correspondence in his office, explaining the conspicuous absence of published papers from to In October , Welch appealed to the board of the Rockefeller Institute to take over the journal. The transfer of ownership and publication responsibilities required the physical transfer of manuscripts from Welch's office, which fell to the director of the Rockefeller Institute, Simon Flexner , who carried the abandoned manuscripts from Baltimore to New York City in a suitcase. The first issue published by the Rockefeller Institute appeared in February , with Flexner serving as editor, and the journal has been published regularly since then. Although the journal was adopted by the Rockefeller Institute as a venue for publication of the institute's own research, it also accepted submissions from outside. Even in the early years, more than half of the papers published in the journal came from external labs.

Case Control Study.

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She has been a professional editor since when she joined Journal of Experimental Medicine as a scientific editor. She then pursued her postdoctoral research with Robert Darnell at The Rockefeller University, focusing on RNA-protein crosstalk in neurological diseases. She pursued her postdoctoral work with Abraham Brass and Kate Fitzgerald at University of Massachusetts Medical School, focusing on uncovering novel host factors in viral replication. She then trained with Dr. Jayanta Chaudhuri at the Sloan Kettering Institute. Throughout her training and appointments, her particular focus has been on many aspects relating to B cell biology.

J exp med

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions. Abstract Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. Publication types Research Support, N.

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Chromosome 15 15q abnormality in patients with Prader-Willi syndrome and Angelman syndrome. User Tools Dropdown. View This Issue. Write to the Help Desk. Intrathecal VEGF-C pretreatment promotes lymphatic drainage of brain-derived fluids and improves neurological outcomes after ischemic stroke via reduced microglia-mediated neuroinflammation and increased BDNF signaling. Enhanced costimulatory molecule expression by cDC2 promotes prolonged T cell activation, integrin-dependent macro-clustering, and optimized cytokine sensing. Contents Volume 13 Issue 5 December 20, IL promotes skin autoinflammation. Lymph node microenvironments support Th2 differentiation. Tools Tools. Rockefeller University Press United States.

The intestine plays an important role in nutrient digestion and absorption, microbe defense, and hormone secretion. Although major cell types have been identified in the mouse intestinal epithelium, cell type-specific markers and functional assignments are largely unavailable for human intestine.

Cancer Immunotherapy Update Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological , pathological , and molecular mechanisms that encompass the host response to disease. Special Collections. Close Modal. Journal homepage Online access Online archive. The authors show that early Th2 cell differentiation is driven via prolonged T—DC macro-clustering in lymph nodes and occurs in a skin site-specific manner. Search Dropdown Menu. Research on nanosciences involvement in pharmaceutical education should be reinforced. This manuscript shows that in the absence of cholesterol hydroxylase Ch25h and the resultant reduction in hydroxycholesterol, age-dependent neuroinflammation and neurodegeneration are strikingly reduced in a mouse model of tauopathy. Risk factors for hydroxychloroquine-induced arrhythmia. The journal has no single editor-in-chief , but thirteen academic editors. March 13