White tablet 377

The pill is an elliptical or oval-shaped, white-colored tablet with an imprint of "". It has been identified to contain tramadol hydrochloride in the strength of 50 mg.

Tramadol is a prescription medication used to treat moderate to moderately severe pain in adults. Tramadol belongs to a group of drugs called opioid analgesics, which work by blocking pain signals in the body. This medication comes in immediate release tablet and that can be taken up to 6 times a day, with or without food. Tramadol also comes in extended-release tablet and capsule forms and are taken once a day, with or without food. Do not chew, divide, or break tramadol extended-release forms. Swallow them whole.

White tablet 377

If you are a consumer or patient please visit this version. Tramadol hydrochloride tablet, USP is a centrally acting analgesic. Its structural formula is:. The molecular weight of tramadol hydrochloride, USP is Tramadol hydrochloride, USP is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9. In addition, each tablet contains the following inactive ingredients: pregelatinized starch, lactose anhydrous, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, titanium dioxide. Tramadol hydrochloride is a centrally acting synthetic opioid analgesic. Tramadol-induced analgesia is only partially antagonized by the opiate antagonist naloxone in several animal tests. Tramadol has been shown to inhibit reuptake of norepinephrine and serotonin in vitro , as have some other opioid analgesics. These mechanisms may contribute independently to the overall analgesic profile of tramadol hydrochloride tablets. Analgesia in humans begins approximately within one hour after administration and reaches a peak in approximately two to three hours.

Consideration should be given to the use of non-narcotic analgesics in patients who are suicidal or depressed [see Drug Abuse and Dependence 9 ]. Carbon dioxide CO 2 retention from opioid-induced respiratory depression can exacerbate the sedating effects of opioids, white tablet 377.

If you are a consumer or patient please visit this version. Dosage and Administration 2. Warnings and Precautions 5. Tramadol hydrochloride tablets are an opioid agonist indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate 1. Limitations of Use 1. Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options [e. Life-Threatening Respiratory Depression.

If you are a consumer or patient please visit this version. Dosage and Administration 2. Warnings and Precautions 5. Tramadol hydrochloride tablets are an opioid agonist indicated in adults for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate 1. Limitations of Use 1. Because of the risks of addiction, abuse, and misuse with opioids, which can occur at any dosage or duration, reserve tramadol hydrochloride tablets for use in patients for whom alternative treatment options [e. Life-Threatening Respiratory Depression. Serious, life-threatening, or fatal respiratory depression may occur with use of tramadol hydrochloride tablets, especially during initiation or following a dosage increase. To reduce the risk of respiratory depression, proper dosing and titration of tramadol hydrochloride tablets are essential [ see Warnings and Precautions 5. Accidental ingestion of even one dose of tramadol hydrochloride tablets, especially by children, can result in a fatal overdose of tramadol [ see Warnings and Precautions 5.

White tablet 377

Mary's Medical Park Pharmacy. Tramadol hydrochloride tablet, USP is a centrally acting analgesic. Its structural formula is:. The molecular weight of tramadol hydrochloride, USP is Tramadol hydrochloride, USP is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9. In addition, each tablet contains the following inactive ingredients: pregelatinized starch, lactose anhydrous, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, titanium dioxide, hypromellose and polysorbate Tramadol hydrochloride is a centrally acting synthetic opioid analgesic.

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Age: Geriatric Healthy elderly subjects aged 65 to 75 years have plasma tramadol concentrations and elimination half-lives comparable to those observed in healthy subjects less than 65 years of age. The volume of distribution of tramadol was 2. Abuse and addiction are separate and distinct from physical dependence and tolerance. Tell your doctor about all the medicines you take including prescription and non-prescription medicines,. In animal reproduction studies, tramadol administration during organogenesis decreased fetal weights and reduced ossification in mice, rats, and rabbits at 1. Abuse Tramadol has mu-opioid agonist activity. One metabolite O-desmethyltramadol, denoted M1 is pharmacologically active in animal models. The minimum effective analgesic concentration will vary widely among patients, especially among patients who have been previously treated with opioid agonists. Tramadol should not be given to a child younger than 12 years old. Abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects. A causal relationship between tramadol hydrochloride tablets and these events has not been determined. In studies including geriatric patients, treatment-limiting adverse events were higher in subjects over 75 years of age compared to those under 65 years of age. Drug addiction is a treatable disease, utilizing a multidisciplinary approach, but relapse is common. To improve the likelihood of a successful taper and minimize withdrawal symptoms, it is important that the opioid tapering schedule is agreed upon by the patient.

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Alternatively, consider the use of non-opioid analgesics in these patients. Shop for Medicare plans. Tramadol hydrochloride tablets -treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosage of tramadol hydrochloride tablets [see Warnings and Precautions 5. Tramadol M1. Neonatal Opioid Withdrawal Syndrome Prolonged use of tramadol hydrochloride tablets during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. The information available does not identify any particular opioids as being more likely to be associated with adrenal insufficiency. You should not take tramadol if you are allergic to it, or if you have:. Advise pregnant women using opioids for an extended period of time of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available [see Use in Specific Populations 8. Advise patients not to perform such tasks until they know how they will react to the medication [see Warnings and Precautions 5. If concomitant use is necessary, consider dosage reduction of tramadol hydrochloride tablets until stable drug effects are achieved.