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Purpose: This European Organisation for Research and Treatment of Cancer phase III trial assesses whether adjuvant whole-brain radiotherapy WBRT increases the duration of functional independence after surgery or radiosurgery of brain metastases. Patients and methods: Patients with one to three brain metastases of solid tumors small-cell lung cancer excluded with stable systemic disease or asymptomatic primary tumors and WHO performance status PS of 0 to 2 were treated with complete surgery or radiosurgery and randomly assigned to adjuvant WBRT 30 Gy in 10 fractions or observation OBS. Results: Of patients, underwent radiosurgery, and underwent surgery. Conclusion: After radiosurgery or surgery of a limited number of brain metastases, adjuvant WBRT reduces intracranial relapses and neurologic deaths but fails to improve the duration of functional independence and overall survival. Abstract Purpose: This European Organisation for Research and Treatment of Cancer phase III trial assesses whether adjuvant whole-brain radiotherapy WBRT increases the duration of functional independence after surgery or radiosurgery of brain metastases.

Ufuk obs

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Ufuk obs

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