Tigecycline tablets

Tigecycline injection is used to treat bacterial infections in many different parts of the body eg, tigecycline tablets, infections on the skin, stomach, or lungs. It works by killing bacteria or preventing their growth.

Federal government websites often end in. The site is secure. Tigecycline is the first drug in the glycylcycline class of antibiotics. Although it is structurally related to minocycline, alterations to the molecule resulted in its expanded spectrum of activity and decreased susceptibility to the development of resistance when compared with other tetracycline antibiotics. Tigecycline has a broad spectrum of activity, including activity against drug-resistant gram-positive organisms. Randomized trials have shown tigecycline to be efficacious for the treatment of complicated intraabdominal infections and complicated skin and skin structure infections.

Tigecycline tablets

Tigecycline , sold under the brand name Tygacil , is a tetracycline antibiotic medication for a number of bacterial infections. It was developed in response to the growing rate of antibiotic resistant bacteria such as Staphylococcus aureus , Acinetobacter baumannii , and E. It was given a U. Tigecycline is used to treat different kinds of bacterial infections, including complicated skin and structure infections, complicated intra-abdominal infections and community-acquired bacterial pneumonia. Tigecycline is given intravenously and has activity against a variety of Gram-positive and Gram-negative bacterial pathogens, many of which are resistant to existing antibiotics. Tigecycline successfully completed phase III trials in which it was at least equal to intravenous vancomycin and aztreonam to treat complicated skin and skin structure infections , and to intravenous imipenem and cilastatian to treat complicated intra-abdominal infections. It has no activity against Pseudomonas spp. The drug is licensed for the treatment of skin and soft tissue infections as well as intra-abdominal infections. Most C. Tigecycline can also be used in vulnerable populations such as immunocompromised patients or patients with cancer. It is well established that tigecycline works as an effective antibiotic, however it may have other properties that are not yet fully understood. The antileukemic activity of tigecycline can be attributed to the inhibition of mitochondrial protein translation in eukaryotic cells.

Common side effects of tigecycline include nausea and vomiting.

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Tigecycline , a derivative of the tetracycline minocycline , is the first available glycylcycline antibiotic Overview of Antibacterial Drugs Antibacterial drugs are derived from bacteria or molds or are synthesized de novo. Tigecycline inhibits protein synthesis by binding to the 30S ribosomal subunit. It is bacteriostatic. Tigecycline is given IV. However, because of its extensive distribution into tissue, blood levels are low, so tigecycline is probably not a good choice for patients with bacteremia especially those with intravascular sources of infection. Most of the drug is excreted in bile and feces.

Tigecycline tablets

Medindia » Drugs » Tigecycline. Follow MedIndia. Tigecycline Price of 6 Brands. The Price section compares costs of the same generic drugs across brands and is purely for information purpose. Medindia neither buys nor sells drugs.

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A single copy of these materials may be reprinted for noncommercial personal use only. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Tigecycline does not require dose changes in people with poor kidney function or having hemodialysis. To avoid the development of resistance, tigecycline should not be used for infections caused by gram-positive organisms only, unless other agents have failed to work. Advertising Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. For non-prescription products, read the label or package ingredients carefully. American Journal of Health-System Pharmacy. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tigecycline successfully completed phase III trials in which it was at least equal to intravenous vancomycin and aztreonam to treat complicated skin and skin structure infections , and to intravenous imipenem and cilastatian to treat complicated intra-abdominal infections. The eradication rate of MRSA was Tigecycline targets both Gram-positive and Gram-negative bacteria including a few key multi-drug resistant pathogens. Tigecycline cSSSI Study Group The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycinaztreonam. Doses are given intravenously over 30 to 60 minutes. Based on this information, dosage adjustments are not recommended in patients with mild or moderate hepatic impairment. These genes code for efflux or ribosomal protection.

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In vitro studies have shown that tigecycline is not extensively metabolized 1. Tigecycline does not inhibit or induce the hepatic cytochrome P enzyme system and is not expected to alter the metabolism of drugs that are metabolized by this system 1. Compared with healthy control subjects, patients with mild hepatic impairment did not have alterations in the pharmacokinetic profile. Effects of age and sex on single-dose pharmacokinetics of tigecycline in healthy subjects. A single copy of these materials may be reprinted for noncommercial personal use only. Tigecycline injection is used to treat bacterial infections in many different parts of the body eg, infections on the skin, stomach, or lungs. Vancomycin was given at a dose of 1 g intravenously every 12 hours and could be adjusted based on renal function. The tetracycline-resistance gene cannot disrupt the tigecycline-ribosome bond, rendering the gene unable to interact with the ribosome and protect it. Tigecycline was shown to increase hepatic enzymes and bilirubin in clinical trials. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. The Infectious Diseases Society of America published updated guidelines for the treatment of complicated intra-abdominal infections in