Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid Bsalvia miltiorrhiza, [3] [4] dihydrotanshinonemiltirone[5] tanshinone Iand tanshinone IIA.

Chinese Medicine volume 5 , Article number: 22 Cite this article. Metrics details. Danshen , the dried root of Salvia miltiorrhiza , is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction.

Salvia miltiorrhiza

Federal government websites often end in. The site is secure. Salvia miltiorrhiza Bunge, also known as Danshen in Chinese, has been widely used to treat cardiovascular diseases CVD in China and other Asia countries. Here, we summarize literatures of the historical traditional Chinese medicine TCM interpretation of the action of Salvia miltiorrhiza, its use in current clinical trials, its main phytochemical constituents and its pharmacological findings by consulting Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, and the Web of Science Databases. Since , 39 clinical trials have been identified that used S. More than individual compounds have been isolated and characterized from S. The isolated compounds may provide new perspectives in alternative treatment regimes and reveal novel chemical scaffolds for the development of anti-CVD drugs. Meanwhile, there are also some rising concerns of the potential side effects and drug-drug interactions of this plant. The insights gained from this study will help us to better understanding of the actions of this herb for management of cardiovascular disorders. As an herb of red root, S. Salvia miltiorrhiza Bunge, also known as red sage or Danshen Chinese Pinyin name , is a perennial plant Fig. Following this first record, S. In the textbooks of academic TCM, S. The herb has been officially recorded in the Chinese pharmacopoeia since According to the Chinese pharmacopoeia [ 2 ], S.

It should be noted that a standardized clinical trial should be randomized, salvia miltiorrhiza, double blind and multi-centered. Effect of Salvia miltiorrhiza hydrophilic salvia miltiorrhiza on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial. Lin, TH.

Salvia miltiorrhiza Bunge SM is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The present review is an up-to-date summary of the published scientific information about the traditional uses, chemical constituents, pharmacological effects, side effects, and drug interactions with SM, in order to lay the foundation for further investigations and better utilization of SM. SM contains diverse chemical components including diterpenoid quinones, hydrophilic phenolic acids, and essential oils. Many pharmacological studies have been done on SM during the last 30 years, focusing on the cardiovascular and cerebrovascular effects, and the antioxidative, neuroprotective, antifibrotic, anti-inflammatory, and antineoplastic activities.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Salvia miltiorrhiza is one of the most widely used traditional medicines. The first gene is involved in the biosynthesis of bioactive tanshinones, the next two are involved in anthocyanin biosynthesis, whereas the last is involved in phenylpropanoid biosynthesis. The results suggest that S. They potentially play significant regulatory roles in the biosynthesis of bioactive compounds. Natural antisense transcripts NATs are a class of long noncoding RNAs, which transcribe in the opposite direction of protein-coding genes 1. Relatively, the transcripts of protein-coding genes were called sense transcripts STs.

Salvia miltiorrhiza

The specific epithet miltiorrhiza means "red ochre root". Chemical compounds isolated from Salvia miltiorrhiza include salvianolic acid or salvianolic acid B , [3] [4] dihydrotanshinone , miltirone , [5] tanshinone I , and tanshinone IIA. The 30 cm 0.

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Tian T. Effective: ST segment elevated by more than 0. Toth P. Henan Med Res. Moderately improved 2. J Tradit Chin Med. Substances Drugs, Chinese Herbal. Curative effect observation of Yixinshu capsule alleviate symptoms of cardiovascular disease. Chin Med. Zhou R. Chinese J Integr Med Cardio-. Ischemic cardiovascular disease 74 1 month. Frequency and duration of angina pectoris attacks decreased.

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Investigation of Danshen and related medicinal plants in China. Lung Cell. Acta Pharmacol Sin. Clinical curative effect observation of perindopril combined with compound Danshen dripping pills in the treatment of hypertension complicated with diabetes in 60 cases. Ineffective 3. Decrease in triglyceride level; Increase in nitric oxide level. Blood routine examination, liver or renal functions, platelet aggregation, levels of fibrinogen and D-dimmer. Ineffective: No improvement in blood pressure. Article PubMed Google Scholar. These funding agencies have no roles in the study design; in data collection, analysis and interpretation; in the writing of the report; and in the decision to submit the article for publication. Chinese Remedies Clin. SOD is a scavenger of superoxide anion and the levels of MDA may reflect the degree of lipid peroxidation. Chin J Neurosurg.