Quinoxaline

A quinoxalinealso called a benzopyrazinein organic chemistryis a heterocyclic compound containing a ring quinoxaline made up of a benzene ring and a pyrazine ring, quinoxaline.

Quinoxaline C8H6N2 , commonly called 1,4-diazanaphthalene, 1,4-benzodiazine, or benzopyrazine, is a very potent nitrogenous heterocyclic moiety consisting of a benzene ring fused with the pyrazine ring. A number of different methods for the synthesis of quinoxaline derivatives have been reported in the literature, but the most effective method, commonly used for the synthesis of quinoxaline analogues involves the condensation of substituted o-phenylenediamines with 1, 2- dicarbonyl compounds in the presence of different catalyst s. The presence of different types of catalysts and their concentration affects the overall yield of the product. Quinoxaline not only plays an important role as an organic reaction intermediate but also has a wide spectrum of interesting biological activities viz. Some commercially available drug molecules containing quinoxaline moiety are echinomycin as antibacterial, antineoplastic, and nucleic acid inhibitor , triostins cyclic desipeptide as an antibacterial agent , dioxidine and mequindox as antibacterial agents , carbadox controlling swine dysentery , desoxycarbadox as swine growth promoter and panadipion as hepatoprotective agent , etc. A large number of quinoxaline analogues possessing different biological activities and their synthetic procedures have been patented worldwide. Keywords: Quinoxaline; antibacterial; anticancer; antioxidant; catalyst; patent information; synthesis.

Quinoxaline

Bioinspired ortho -quinone catalysts have been applied to oxidative synthesis of benzimidazoles, quinoxalines and benzoxazoles from primary amines in high yields under mild conditions with oxygen as the terminal oxidant. Zhang, Y. Qin, L. Zhang, S. Luo, Org. Bains, V. Singh, D. Adhikari, J. Shee, D. Panja, S. Kundu, J. Aerobic oxidation of deoxybenzoins is efficiently catalyzed by 1,4-diazabicyclo[2. The process has been successfully extended to a one-pot synthesis of quinoxalines from benzyl ketones and aromatic 1,2-diamines. Qi, H. Jiang, L.

ISBN quinoxaline The combination of a cobalt catalyst and oxygen as a terminal oxidant mediates an annulation of terminal alkynes and o -phenylenediamines, quinoxaline.

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Federal government websites often end in. The site is secure. Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties antiviral, anticancer, and antileishmanial , ensuring them a bright future in medicinal chemistry. Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives.

Quinoxaline

Federal government websites often end in. The site is secure. Quinoxalines, a class of N -heterocyclic compounds, are important biological agents, and a significant amount of research activity has been directed towards this class. They have several prominent pharmacological effects like antifungal, antibacterial, antiviral, and antimicrobial. Quinoxaline derivatives have diverse therapeutic uses and have become the crucial component in drugs used to treat cancerous cells, AIDS, plant viruses, schizophrenia, certifying them a great future in medicinal chemistry. Due to the current pandemic situation caused by SARS-COVID 19, it has become essential to synthesize drugs to combat deadly pathogens bacteria, fungi, viruses for now and near future. Since quinoxalines is an essential moiety to treat infectious diseases, numerous synthetic routes have been developed by researchers, with a prime focus on green chemistry and cost-effective methods.

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Wei, D. The combination of a cobalt catalyst and oxygen as a terminal oxidant mediates an annulation of terminal alkynes and o -phenylenediamines. Interactive image. Lin, Y. Read Edit View history. Y verify what is Y N? Wang, J. Determination of Organic Structures by Physical Methods. GHS labelling :. Chen, Synlett , , 24 ,

A quinoxaline , also called a benzopyrazine , in organic chemistry , is a heterocyclic compound containing a ring complex made up of a benzene ring and a pyrazine ring.

Bains, V. H , H , H Chemical formula. Hu, X. Singh, D. Chen, H. Interactive image. Precautionary statements. Chemical compound. McLaughlin Org. Quinoxaline C8H6N2 , commonly called 1,4-diazanaphthalene, 1,4-benzodiazine, or benzopyrazine, is a very potent nitrogenous heterocyclic moiety consisting of a benzene ring fused with the pyrazine ring. Xie, W.