Ondansetron drug interactions

Ondansetron belongs to the class of medications called 5-HT3 receptor antagonists. This medication is used to prevent nausea and vomiting associated with certain types of cancer chemotherapy and radiation. It is also ondansetron drug interactions to prevent and treat the nausea and vomiting that occurs after surgery, ondansetron drug interactions. It works by reducing the effects of a naturally-occurring chemical in the body called serotonin, which causes nausea and vomiting.

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet. Ondansetron interactions with amiodarone, domperidone, methadone, specific antiarrhythmic and antibiotic medications, and serotonergic agents. Ondansetron can also affect the metabolism of other medicines, exacerbating side effects associated with individual drugs. The most serious medications that ondansetron interferes with include certain antiarrhythmics, antibiotics, and serotonergic medications. As a selective 5HT3 receptor antagonist , Ondansetron blocks serotonin peripherally and centrally.

Ondansetron drug interactions

Currently viewing BNF. View ondansetron drug monograph. Ondansetron has the following interaction information:. Severe interactions are highlighted with a red marker. Find out more about BNF interactions information. Both Ondansetron and Almotriptan can increase the risk of serotonin syndrome. See 'Serotonin syndrome' and 'Monoamine-oxidase inhibitor' under Antidepressant drugs in BNF for more information and for specific advice on avoiding monoamine-oxidase inhibitors during and after administration of other serotonergic drugs. Both Ondansetron and Amifampridine prolong the QT interval. Most manufacturers advise avoiding the use of two or more drugs that are associated with QT prolongation. Increasing age, female sex, cardiac disease, and some metabolic disturbances notably hypokalaemia predispose to QT prolongation. Aminophylline is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. Manufacturer makes no recommendation. Both Ondansetron and Amiodarone prolong the QT interval. Both Ondansetron and Amisulpride prolong the QT interval. Amphotericin B is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron.

Skip to main content Search for a topic or drug. Prevention of delayed chemotherapy-induced nausea and vomiting after moderately high to highly emetogenic chemotherapy: comparison of ondansetron, prochlorperazine, and dexamethasone.

Federal government websites often end in. Before sharing sensitive information, make sure you're on a federal government site. The site is secure. NCBI Bookshelf. Alexandria Griddine ; Jeffrey S. Authors Alexandria Griddine 1 ; Jeffrey S.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Ondansetron drug interactions

Key takeaways Drug interactions Food interactions Other interactions Avoiding interactions When to see a doctor. Ondansetron , known under the brand name Zofran , is a selective 5-HT3 receptor antagonist that functions as an antiemetic to aid in the prevention of nausea and vomiting from chemotherapy or radiation therapy , treatment of severe and acute nausea and vomiting and the prevention and treatment of postoperative nausea and vomiting. Ondansetron is available as an injection, an oral solution, an oral tablet, and an orally-disintegrating tablet.

Maddison twins nude

Bulk Download. Ondansetron is not approved for use by anyone younger than 4 years old. J Matern Fetal Neonatal Med. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. The recommended adult dose of ondansetron to prevent nausea and vomiting caused by surgery is 16 mg taken by mouth, 1 hour before anesthesia. Do alcohol and hydroxyzine mix? Both Ondansetron and Linezolid can increase the risk of serotonin syndrome. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. Current evidence does not demonstrate a need to pre-screen this population before administering ondansetron for patients without any of the above risk factors. Both Ondansetron and Pazopanib prolong the QT interval. The mechanism of the interaction remains unknown, but apomorphine prescribing information reports cases of profound hypotension and resultant loss of consciousness due to concomitant use of it with ondansetron. Using alcohol or tobacco with certain medicines may also cause interactions to occur.

.

Sharing options Share Icon. Tricyclic antidepressants TCAs include:. Blood pressure meds for ED Feb. Supplementary concepts AMF protocol. Breastfeeding Considerations: In a pharmacokinetic study, the relative infant exposure to ondansetron is less. Triamcinolone is predicted to cause hypokalaemia potentially increasing the risk of torsade de pointes when given with Ondansetron. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. There are limited data available from pediatric populations. Both Ondansetron and Anagrelide prolong the QT interval. Fingolimod might increase the risk of QT-prolongation when given with Ondansetron. The pattern of liver enzyme elevation is normally hepatocellular, with rare cases of clinically apparent acute liver injury or jaundice.