Norleucine

Quantitative norleucine services for biomarker discovery and validation. Your source for quantitative metabolomics technologies and bioinformatics. You are using an unsupported browser, norleucine.

A systematic name for this compound is 2-aminohexanoic acid. It is a white, water-soluble solid. Together with norvaline , norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar. Its biosynthesis has been examined. The incorporation of Nle into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. In Miller—Urey experiments probing prebiotic synthesis of amino acids, norleucine and especially norvaline are formed.

Norleucine

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Federal government websites often end in. The site is secure. The broadly active glutamine antagonist 6-diazooxo-L-norleucine DON has been studied for sixty years as a potential anticancer therapeutic. Clinical studies of DON in the s using low daily doses suggested antitumor activity, but later phase I and II trials of DON given intermittently at high doses were hampered by dose-limiting nausea and vomiting. Further clinical development of DON was abandoned. Recently the recognition that multiple tumor types are glutamine dependent has renewed interest in metabolic inhibitors such as DON. Here we describe the prior experience with DON in humans.

Norleucine

We are working on a new version of ChemSpider — if you want to try the new interface go to beta. Simple Structure Advanced History. Comment on this record. Featured data source. S Aminocaproic acid. S amino-Hexanoi c acid. S Aminohexanoic acid. S -a-Aminocaproic acid. S -Aminohexanoic a cid.

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View Spectrum. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Fermentative production of L-norleucine. Organic compounds. CAS Number. Carboxylic acids and derivatives. Property Value Source Water Solubility. Quantitative metabolomics services for biomarker discovery and validation. Solubility in water. Untitled Document-3 MrvD 9 8 0 0 0 0 V Not Available. Value Source S Aminohexanoic acid. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. Non-proteinogenic amino acids. You are using an unsupported browser.

A systematic name for this compound is 2-aminohexanoic acid. It is a white, water-soluble solid. Together with norvaline , norleucine is found in small amounts in some bacterial strains where its concentration can approach millimolar.

These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Cancer Metab. Property Value Source Water Solubility. Download PDF. Download as PDF Printable version. Read Edit View history. It is nearly isosteric with methionine , even though it does not contain sulfur. EC Number. Chemical compound. View Spectrum. It is a white, water-soluble solid. L-Norleucine is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. Organic compounds. Kokai Tokkyo Koho , 4 pp.