Michelle miranda

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Michelle miranda

Her research interest lies in bridging science and medicine by implementing core chemistry to study and improve human health. Michelle M. Print Profile Email Profile. Bio Publications. Links Dodd Lab. Nonreplicating Mycobacterium tuberculosis Mtb is extremely difficult to eradicate using current TB drugs that primarily act on replicating cells. Novel TB drugs acting on unconventional targets are needed to combat TB efficiently. Although membrane-disrupting antimicrobial peptides and their synthetic mimics exhibit the potential to kill persisters, the lack of microbe selectivity, especially toward mycobacteria, has been a concern. Here, we report that the recently developed poly guanylurea -piperazine PGU-P shows fast and selective mycobactericidal effects. Using a nonpathogenic model organism, Mycobacterium smegmatis Msm , we have found that the mycobactericidal effects of PGU-P are correlated to the disruption of the mycobacterial membrane potential and bioenergetics. Accordingly, PGU-P also potentiates bedaquiline, an oxidative phosphorylation-targeting TB drug disturbing mycobacterial bioenergetics.

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Her research interest lies in bridging science and medicine by implementing core chemistry to study and improve human health. Mycobacterial infectious diseases, including tuberculosis TB , severely threaten global public health. Nonreplicating Mycobacterium tuberculosis Mtb is extremely difficult to eradicate using current TB drugs that primarily act on replicating cells. Novel TB drugs acting on unconventional targets are needed to combat TB efficiently. Although membrane-disrupting antimicrobial peptides and their synthetic mimics exhibit the potential to kill persisters, the lack of microbe selectivity, especially toward mycobacteria, has been a concern. Here, we report that the recently developed poly guanylurea -piperazine PGU-P shows fast and selective mycobactericidal effects. Using a nonpathogenic model organism, Mycobacterium smegmatis Msm , we have found that the mycobactericidal effects of PGU-P are correlated to the disruption of the mycobacterial membrane potential and bioenergetics.

Michelle Fuentes-Miranda is a community leader and youth development professional with over 25 years of experience as a teacher, school principal, youth program director, and nonprofit administrator. In this role, she has significantly expanded the array of services available to high-barrier youth in the West San Fernando Valley and has been regionally and nationally recognized for leadership and service in effectively meeting the needs of the community. She has also played a significant role in bridging relationships amongst a range of business, government, community groups, and organizations active in civil activism, public safety, and human services, and civic engagement. Inspired by the spirit of service and entrepreneurialism demonstrated by her grandmother, Michelle founded Alliance for Community Empowerment ACE to help disenfranchised young people transform their lives and their communities through leadership development, education, and civic engagement. ACE continues to expand its services to meet a wider range of community needs through collaboration, service, and community action.

Michelle miranda

Before I started out in forensics 20 years ago, I served in the military. I was a communications engineer in the army, radios were my domain. After I left, someone suggested I turn to digital forensics. Nearly everything I do starts with a device — a phone or computer. I want anything and everything I can get my teeth into, seeking information and clues. Phones just used to do texts and calls. The trouble is, even the most basic technology can be used by criminals to their advantage, making my job harder. Much of the information I can glean from mobile devices comes from traces of communication pinging around different corners of the internet. Global criminal networks can avoid this in a very simple way, for instance, by logging into an email account online, writing a message and leaving it in the drafts folder. Someone else can then sign in, read and respond without leaving a trace.

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My progression from Assistant QS, to a qualified QS when I achieved my RICS chartership, and to being a Regional Director now was therefore less of me deciding this path, but more of a professional advancement and personal growth through perseverance, dedication and most importantly helping those around me fulfil their potential as well. In Practice for 11 Years. Privacy Terms Help. I will bill in-network insurers. I still enjoy being a QS and so I also still get involved in QS tasks and deliverables where my support is needed, including agreeing contract sums, collating contract documentations, preparing cost plans and even visiting site for valuations! Physician-Scientist Development Awards. Brode Ed. Verified email at uvic. Bayesian statistics machine learning neuroimaging functional data analysis. Adults ,. Saunders Eds. Our results support that PGU-P is a novel class of antimycobacterial biomaterial, and the unique structural feature can contribute to developing novel antimycobacterial drugs. Dean's Workshop.

Welcome to Crescent Moon Psychiatry! It has always been my goal to care for others, and I have found that psychiatry allows me to truly understand another person, thus allowing me to provide a holistic level of care. Since then, I have had the unique experiences of working at a psychiatric emergency department, an inpatient psychiatric hospital setting, and an intensive outpatient substance abuse treatment program.

Understand that therapy is not a quick fix, but a process. Project Team. Giving to YSM. Experiential Learning Subcommittee. It most likely took you a while to get where you are now, so it may take awhile to get to where you want to be. Mycobacterial infectious diseases, including tuberculosis TB , severely threaten global public health. What advice would you give a young woman aspiring to progress to senior level in the industry? What does your Senior Role Title actually involve? Childcare Survey and Data Display. Michelle D. Call or Email Michelle Miranda now for a free 15 minute consultation - New articles related to this author's research. Lesbian Allied ,. Gay Allied ,.