Macquarie university dementia research centre

Lars graduated from the University of Ulm in Germany and completed his thesis at the University … View full profile.

Please also feel free to contact us if you are not eligible for any of the studies below, or if you have any suggestions or questions. We will keep you in mind for our next study or put you in contact with other researchers who may be able to help you. You will also do some cognitive tests, answer questionnaires, provide a blood sample and have some body measurements taken. You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. After that you will receive information on studies you are eligible for and you can decide if you would like to participate.

Macquarie university dementia research centre

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver. Hence, there is an unmet need for new therapeutic avenues in dementia. The multidisciplinary team of the Dementia Research Centre works closely with medicinal chemists and international pharmaceutical industry to accelerate translation into novel therapies for these devastating diseases. To treat dementia, it is vital to first understand the processes that lead to neuronal dysfunction and brain atrophy. Here, the team of the Dementia Research Centre has made fundamental discoveries that shed new light on the causes of dementia. The current discovery research program of the Dementia Research Centre strives to identify novel disease mechanisms and reveal new avenues to treat these devastating conditions. To achieve this aim, our different discovery research programs investigate a broad range of molecular processes, including the roles of cytoskeleton dynamics , kinase signalling and RNA regulation in normal brain function and disease. Research into disease mechanisms as well as developing and testing new drugs for dementia heavily relies on good disease models. These models need to accurately recapitulate aspects of the human conditions and at the same time be assessible for experimental manipulation. The team at the Dementia Research Centre has extensive experience with the development of both cell culture-based and animal models of dementia. Neuropathology provides the unique opportunity to visualise disease-specific protein abnormalities and the cell types and brain regions affected that cause neurodegeneration.

The past decades of drug development have focused on clearing amyloid or reducing its formation but unfortunately have all failed to deliver.

The DRC currently includes eight research groups. The teams at the Dementia Research Centre currently have more than 10 different therapeutic development programs at different stage of pre-clinical testing. These include small molecules, antibodies and gene therapy approaches. Most of these proprietary molecules and drug targets are based on novel discoveries of disease mechanisms made over the past decade. AAVs are particularly well suited for gene delivery into cells and living organisms, including for gene therapy in humans. Operating our own AAV core allows immediate access to this cutting-edge technology for all our research teams, accelerating multiple discovery research projects and our gene-therapy pipeline.

View more. The researcher will also integrate into ongoing research projects focusing on understanding disease mechanisms in dementia. The role will involve administering and testing novel gene therapies in a range of mouse models for various neurological disorders including epilepsy and dementia , as well as further developing and testing novel gene therapies in various cell culture systems. The role requires significant independence in experimental planning and execution, data analysis and reporting. The successful candidate will present the data at scientific conferences and contribute to the preparation of manuscripts towards publications in scientific journals. You will have worked with laboratory animals in your field of research and you are interested in utilising these to test and assess a range of novel AAV-based gene therapies. Experience with behavioural, biochemical, and histological analysis of rodents is highly desirable. You will also have experience with Mass Spectrometry for the analysis of biological samples.

Macquarie university dementia research centre

Research output Research output per year 67 Article 12 Review article 3 Chapter 2 Editorial 1 More 1 Preprint. Research output per year. Open Access. An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting Wong, C. Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy Forrest, S. Current concepts of mixed pathologies in neurodegenerative diseases Forrest, S. Dysregulated actin dynamics and cofilin correlate with TDP pathology in sporadic amyotrophic lateral sclerosis Jagaraj, C.

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Emily is currently a PhD candidate with the Dementia Research Centre focusing on inhibitory interneurons in Alzheimer's disease. The current discovery research program of the Dementia Research Centre strives to identify novel disease mechanisms and reveal new avenues to treat these devastating conditions. Andrea is a research assistant responsible for histology and tissue processing at the Dementia Research Centre, Faculty of Medicine and Health Science. Ke group team members. E-mail: emily. DP Transcriptional and translational regulation of the neuronal protein tau Ittner, L. Liming Hou completed her Ph. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. Previously working as a researcher and lecturer at the Key Laboratory … View full profile. The multidisciplinary team of the Dementia Research Centre works closely with medicinal chemists and international pharmaceutical industry to accelerate translation into novel therapies for these devastating diseases.

Our vision is a world without MND.

You may chose to have an optional lumbar puncture to collect cerebral spinal fluid CSF. Organisation profile. After that you will receive information on studies you are eligible for and you can decide if you would like to participate. She then began working a… View full profile. Adeno-associated virus core The Dementia Research Centre operates its own core facility for the production of adeno-associated viruses AAV. The DRC currently includes eight research groups. Projects per year. Julia van der Hoven completed her Bachelor of Science majoring in physiology and pharmacology at The University of Sydney in At the same time these 2D cultures do not resemble the complexity of the brain. After working in community … View full profile. E-mail: lars.