Jomon joseph

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Jomon joseph

The system can't perform the operation now. Try again later. Citations per year. Duplicate citations. The following articles are merged in Scholar. Their combined citations are counted only for the first article. Merged citations. This "Cited by" count includes citations to the following articles in Scholar. Add co-authors Co-authors. New articles by this author. New citations to this author. New articles related to this author's research. Email address for updates.

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J Cell Sci 15 February ; 4 : jcs Nuclear export of mRNAs is a critical regulatory step in eukaryotic gene expression. However, the regulatory mechanisms underlying these interactions are unclear. This article has an associated First Person interview with the first author of the paper. Association of various RNA-binding proteins RBPs with mRNAs during and after transcription, forming nuclear messenger ribonucleoprotein particles mRNPs , facilitates nuclear export and determines the fate of the mRNAs in terms of their stability, cytoplasmic localization and translation Carmody and Wente, ; Dreyfuss et al. Amino acids are numbered. The cells were subjected to co-immunoprecipitation co-IP using GFP-specific antibody and the IP samples were analyzed by western blotting WB using indicated antibodies. Molecular mass markers are as indicated. The IP samples were analyzed by WB using indicated antibodies. GAPDH was used as loading control.

Jomon joseph

Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Untreated, this condition leads to seizures, coma, long-term neurological damage and a high rate of mortality. In , Derek Neilson and colleagues published a seminal paper where they reported that three separate dominant missense mutations in the RANBP2 gene were associated with Acute Necrotizing Encephalopathy ANE , a pediatric condition where otherwise normal individuals develop a cytokine storm localized primarily to the central nervous system in response to viral infection [ 1 ]. Not many inherited genetic diseases are caused by dominant mutations, in part because they can affect all carriers, although many severe neurological disorders can be caused by de novo dominant mutations. How these mutations cause ANE remains unclear [for excellent recent reviews on this topic see 2 , and 3 ]. The eight filaments sit on top of the outer ring, which is composed of sixteen copies of the Y-shaped coat nup complex. The five copies are held together by an oligomerization element.

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