Free radic res

Free radicals and other reactive oxygen species ROS are constantly formed in the human body. Free-radical mechanisms have been free radic res in the pathology of several human diseases, including cancer, atherosclerosis, malaria, and rheumatoid arthritis and neurodegenerative diseases, free radic res. Catalases in peroxisomes convert H 2 O 2 into water and O 2 and help to dispose of H 2 O 2 generated by the action of the oxidase enzymes that are located in these organelles. Other important H 2 O 2 -removing enzymes in human cells are the glutathione peroxidases.

Free Radical Research , formerly Free Radical Research Communications , is an academic journal that publishes research papers, hypotheses, and reviews on free radicals , redox signaling , antioxidants , and oxidative damage. It is published by Informa Healthcare. Free Radical Research publishes 12 issues per year in simultaneous print and online editions. Contents move to sidebar hide. Article Talk.

Free radic res

Federal government websites often end in. The site is secure. In recent years, there has been a great deal of attention toward the field of free radical chemistry. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence application of external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases. The recent growth in the knowledge of free radicals and reactive oxygen species ROS in biology is producing a medical revolution that promises a new age of health and disease management. Free radicals and antioxidants have become commonly used terms in modern discussions of disease mechanisms.

Ramotar, D. Chen, T. Free radicals can be produced from non-enzymatic reactions of oxygen with organic compounds as well as those initiated by ionizing radiations.

Informa Healthcare. How to publish in this journal. The set of journals have been ranked according to their SJR and divided into four equal groups, four quartiles. Q1 green comprises the quarter of the journals with the highest values, Q2 yellow the second highest values, Q3 orange the third highest values and Q4 red the lowest values. The SJR is a size-independent prestige indicator that ranks journals by their 'average prestige per article'.

Acute kidney injury AKI is a major kidney disease associated with poor clinical outcomes. Oxidative stress is predominantly involved in the pathogenesis of AKI. Autophagy and the Keap1-Nrf2 signalling pathway are both involved in the oxidative-stress response. However, the cross talk between these two pathways in AKI remains unknown. Here, we found that autophagy is upregulated during cisplatin-induced AKI. In contrast with previous studies, we observed a marked increase in p We also found that p62 knockdown reduces autophagosome formation and the expression of LC3II. To explore the cross talk between p62 and the Keap1-Nrf2 signalling pathway, HK-2 cells were transfected with siRNA targeting Nrf2, and we found that Nrf2 knockdown significantly reduced cisplatin-induced p62 expression. These results indicate that p62 creates a positive feedback loop in the Keap1-Nrf2 signalling pathway. Finally, we examined the role of p62 in cell protection during cisplatin-induced oxidative stress, and we found that p62 silencing in HK-2 cells increases apoptosis and reactive oxygen species ROS levels, which further indicates the protective role of p62 under oxidative stress and suggests that the cytoprotection 62 mediated is in part by regulating autophagic activity or the Keap1-Nrf2 signalling pathway.

Free radic res

Objectives: The goal of our study was to investigate the associations of oxidized LDL apoB aldehyde-modified form and acute phase proteins fibrinogen, CRP with acute ischemic stroke severity and outcome. Materials and methods: The study included 61 ischemic stroke patients and 64 controls. Strokes were subtyped according to TOAST criteria, the severity and outcome of stroke at 1 year were measured. Results: The mean triglyceride, fibrinogen, CRP and glucose values were significantly higher among cases. The median oxLDL value for patients with large artery atherosclerosis LAA type of stroke was significantly higher than for other subtypes. The oxLDL values did not correlate with age, stroke severity and outcome.

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Pharmacogn Rev. Keogh, F. Stocker, and M. Oxidative damage to protein products may affect the activity of enzymes, receptors, and membrane transport. Dietary factors associated with death rates from certain neoplasms in man. Many of these are present in medicinal plants. Pou, and G. Received Mar 26; Accepted May 5. Modulation of energy status and cytotoxicity induced by FK and cyclosporin A in a renal epithelial cell line. Google Scholar Download references. Fairlamb AH, Cerami A. Significance of melatonin in antioxidative defense system: Reactions and products. J Physiol Biochem. Breen, A.

It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypothesis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ionizing irradiation IR -induced Human Lymphocyte AHH-1 cells apoptosis and increase cells viability in vitro.

Synthetic antioxidants are recently reported to be dangerous to human health. Roberfroid MB. Haile, J. Although the precise mechanism and site of radical formation in vivo are not well elucidated yet, the metal-induced decompositions of hydroperoxides and hydrogen peroxide must be one of the important sources. Britigan, M. Google Scholar Gaston, B. Antioxidant supplementation. Kumpulainen, J. Vitamin E: Action, metabolism and perspectives. Indeed, our health also depends on our lifestyle choice. Vitamin E is a fat-soluble vitamin with high antioxidant potency. Reznick, A. The isoprostanes: Novel prostanglandin-like products of the free radical catalyzed peroxidation of arachidonic acid. Food Chem Toxicol. Effects of nutritional supplementation with antioxidant vitamins and minerals and fish oil on antioxidant status and psychosocial stress in smokers: an open trial.