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Image by Asad Amin from Pixabay. In the last several days there has been a lot of talk about videos on YouTube and YouTube Kids that are inappropriate for our children. One of those videos, free mom tube, the cartoon with the suicide clip, was brought to light right here on PediMom. I wish I could say that free mom tube are isolated incidents but unfortunately I cannot.

Federal government websites often end in. The site is secure. Neural tube defects NTDs are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. It is established that folic acid supplementation decreases the prevalence of NTDs, which has led to national public health policies regarding folic acid. However, several lines of evidence suggest that not only folates but also choline, B12 and methylation metabolisms are involved in NTDs. Decreased B12 vitamin and increased total choline or homocysteine in maternal blood have been shown to be associated with increased NTDs risk.

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Federal government websites often end in. The site is secure. Opioid medications are among the most effective analgesics. However, the consequences of opioid exposure to the developing human offspring are not known. We assessed whether maternal opioid use in the periconceptional period was associated with the risk of neural tube defects in the offspring. Mothers were interviewed by telephone within 6 months of delivery about sociodemographic factors and exposures during pregnancy including detailed questions on type and timing of medication use. Mothers of offsprings with neural tube defect were compared with mothers of 7, offsprings in the nonmalformed control group and 13, offsprings in the malformed control group. Periconceptional opioid use was defined as any reported use in the 2 months after the last menstrual period. A higher percentage of mothers of offsprings with neural tube defects 3. When offsprings were restricted to those with spina bifida, the adjusted ORs were 2. Overall, opioid use in the periconceptional period appeared to be associated with a modest increased risk of neural tube defects. Opioid medications are effective analgesics and are among the most commonly prescribed drugs in the United States. Opioids cross the placenta 9 and have been detected in the umbilical cord, placenta, and meconium, 10 , 11 but the effects of opioid exposure on the developing human fetus are not known. The objective of our study was to examine whether the risks of neural tube defects were increased among mothers with opioid use in the periconceptional period, the gestational time of neural tube defect development, and whether risks were higher for subgroups of opioid medications. The study began in and the methods have been previously described in detail.

Decline in prevalence of neural tube defects in a high-risk region of the United States. Annu Rev Nutr. Homocysteine metabolism in families from southern Italy with neural tube defects: Role of genetic and nutritional determinants.

Federal government websites often end in. The site is secure. Folate vitamin B 9 is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for folate increase during pregnancy because it is also required for growth and development of the fetus. Folate deficiency has been associated with abnormalities in both mothers anemia, peripheral neuropathy and fetuses congenital abnormalities. This article reviews the metabolism of folic acid, the appropriate use of folic acid supplementation in pregnancy, and the potential benefits of folic acid, as well as the possible supplementation of l -methylfolate for the prevention of pregnancy-related complications other than neural tube defects.

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Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster. Although a complete detailing of the role of these nutrients in erythropoiesis is beyond the scope of this review, it is important to understand that the reaction in normal erythropoieses involving both folate and vitamin B 12 is the transfer of a methyl group from l -methylfolate to homocysteine via methylcobalamin for the regeneration of methionine. Implications for prevention. Fed Proc. Pietrzyk J. Manchikanti L, Singh A. National Programs for NTDs Prevention There are three potential approaches for the delivery of folic acid to the general population: improvement of dietary habits, fortification of food and use of supplements [ 59 ]. Watanabe M. In most cases, a child may need surgery before or after birth. Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Food fortification significantly increased serum and RBC folates among childbearing-aged women and decreased the prevalence of low folate concentrations [ 62 , 63 , 64 , 65 , 66 ]. Public Health.

This website contains age-restricted materials including nudity and explicit depictions of sexual activity. By entering, you affirm that you are at least 18 years of age or the age of majority in the jurisdiction you are accessing the website from and you consent to viewing sexually explicit content. Our parental controls page explains how you can easily block access to this site.

Simmons C. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Folic acid and homocyst e ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Although additional studies are needed to better define the precise timing, dosing, and formulation, existing data suggest that dietary folic acid supplementation is a good idea for all reproductiveaged women. The most frequently reported reason for using an opioid among all mothers was pain followed by headache Table 2. Van der Put et al. Trends in use of benzodiazepines, opioids, tramadol, and Z-drugs from to in a managed care population. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Christensen et al. Folate and Methylation Metabolism Folate is an essential water soluble B-vitamin provided in the diet, particularly from fruits and vegetables. Reduction in neural-tube defects after folic acid fortification in Canada. Periconceptional folic acid supplementation protects against fetal structural anomalies, including neural tube and congenital heart defects. When the data were restricted to offsprings with spina bifida, the adjusted OR was 2.