Fernanda cisneros

Handling Editor: David Glover. Nuno M. Earnshaw; H3K9me3 fernanda cisneros on a human artificial chromosome is required for segregation but not centromere epigenetic memory.

Background: In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. In particular, miRb1 has been suggested to be an miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers. In the present study, we evaluated the DNA methylation at the CpG island proximal to the transcription start site of miRb1 in cancer cell lines as well as in normal tissues and gynecological tumor samples. In addition, we analyzed the association of CTCF and covalent histone modifications at the miRb1 locus. CTCF repressive histone marks abundance was evaluated by chromatin immunoprecipitation assays.

Fernanda cisneros

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Received: 10 Dec Peer review history. Cite Icon Cite.

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Our understanding of the structure and function of mitotic chromosomes has come a long way since these iconic objects were first recognized more than years ago, though many details remain to be elucidated. In this chapter, we start with the early history of chromosome studies and then describe the path that led to our current understanding of the formation and structure of mitotic chromosomes. We also discuss some of the remaining questions. It is now well established that each mitotic chromatid consists of a central organizing region containing a so-called "chromosome scaffold" from which loops of DNA project radially. These proteins are concentrated along the axis of the chromatid. Condensins I and II are primarily responsible for shaping the chromosome and the scaffold, and they produce the loops of DNA by an ATP-dependent process known as loop extrusion.

Fernanda cisneros

J Cell Sci 15 July ; 14 : jcs First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Nuno conducted the research described in this article while a PhD student in William C.

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Latest published articles alert. Email alerts Article activity alert. Close Modal. Background: In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. This site. There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now. Twitter LinkedIn Youtube. User Tools Dropdown. Extended submission deadline: 29 March Hiroshi Masumoto , Hiroshi Masumoto. Google Scholar. In particular, miRb1 has been suggested to be an miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers. Hiroshi Kimura.

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Martins Kochanova H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory In collection: Exploring the Nucleus. Accepted manuscripts alert. Twitter LinkedIn Youtube. View full article. All rights reserved. PDF Link Peer review history. Vladimir Larionov , Vladimir Larionov. Online ISSN: Hiroshi Masumoto , Hiroshi Masumoto. This site uses cookies.