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Background and purpose: To describe the characteristics of patients presenting a paraneoplastic cerebellar degeneration without classical onconeural antibodies seronegative PCD. No significant difference between the clinical characteristics of seronegative and seropositive PCD patients was observed. Yet the frequency of associated tumors was different. Seronegative and seropositive PCD patients with similar tumors had a similar overall survival. Conclusion: The clinical characteristics of seronegative and seropositive PCD are similar but the spectrum of associated tumors is different. The immunological scenario of seronegative PCD seems to be different from that of limbic encephalitis with only few patients harboring anti-neuropile antibodies. Keywords: onconeural antibodies; paraneoplastic cerebellar degeneration.

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Access your subscriptions. Close X. The types of PNS included in the database were the classic syndromes reported by Euronetwork et al 3 and several other less well-characterized syndromes associated with cancer, euronetwork.

Background: Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives: To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Design: Prospective case series and database study. Setting: Twenty European centers. Patients Patients were recruited from January 1, , to December 31,

Arch Neurol. Background Paraneoplastic neurologic syndrome PNS represents the remote effects of cancer on the nervous system. Diagnostic criteria for the syndrome were published by the PNS Euronetwork and form the basis of a database to collect standardized clinical data from patients with PNS. Objectives To analyze various types of PNS, frequent tumor and antibody associations, clinical characteristics of individual syndromes, and possible therapeutic and prognostic strategies. Patients Patients were recruited from January 1, , to December 31, Main Outcome Measures Based on diagnostic criteria published by the PNS Euronetwork consortium, clinical characteristics of classic PNS and several other less well-characterized syndromes associated with cancer were assessed.

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Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma. The relative distribution of disorders confirmed cerebellar degeneration and sensory neuronopathy were the most frequently appearing PNS. Psychiatric symptoms Dysautonomic PNS is underdiagnosed because it develops in the setting of at least 1 other PNS, which may dominate the presentation and mask the autonomic features. Study supervision : Vitaliani, Graus, Honnorat, and Bertolini. Publication types Research Support, Non-U. I refuse cookies. A remarkable finding was the poor prognosis of patients with dysautonomia; a tumour was found in 37 out of 51 cases and in 28 of these the diagnosis followed the neurological syndrome with a median time of 4. Infrequently, other tumors such as of the prostate, thymus, and testis were observed. Add or change institution. Between January 1, , and December 31, , the partnership collected information on patients, resulting in the largest database on PNS to date.

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One hundred seventeen patients with features of an SN also had distal motor involvement. Cookies on Companies House services We use some essential cookies to make our services work. A multifocal PNS was found in 94 patients 9. Data were centrally reviewed, and all generated queries were processed at an independent statistical and quality assessment center Mario Negri Institute of Pharmacological Research, Milan, Italy. The structure of the database was maintained throughout the study, and no modifications were permitted. The atypical antibodies were 3. Create a personal account or sign in to:. Treatment of paraneoplastic neurological syndromes with antineuronal antibodies anti-Hu, anti-Yo with a combination of immunoglobulins, cyclophosphamide, and methylprednisolone. The database was constructed based on consensus guidelines by Graus et al 3 for the diagnosis of PNS hereinafter, the Graus criteria. Fourteen patients had dermatomyositis.