Dehp full form

Di 2-ethylhexyl phthalate DEHP is a man-made chemical.

Federal government websites often end in. The site is secure. Diethylhexyl phthalate DEHP is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns about its safety and its potential effects on human health. The main aim of this review is to give an overview of the endocrine, testicular, ovarian, neural, hepatotoxic, and cardiotoxic effects of DEHP on animal models and humans in vitro and in vivo. Diethylhexyl phthalate DEHP is the most common member of the class of phthalates, which are used as plasticizers in polymer products to make plastic flexible.

Dehp full form

DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan circa and in the United States in DEHP has two stereocenters, [8] located at the carbon atoms carrying the ethyl groups. As a result, it has three distinct stereoisomers, [8] consisting of an R , R form, an S , S form diastereomers , and a meso R , S form. As most 2-ethylhexanol is produced as a racemic mixture, commercially-produced DEHP is therefore almost always racemic as well, and consists of equal amounts of all three stereoisomers. It is also used as a hydraulic fluid and as a dielectric fluid in capacitors. DEHP also finds use as a solvent in glowsticks. Approximately three million tonnes are produced and used annually worldwide. Manufacturers of flexible PVC articles can choose among several alternative plasticizers offering similar technical properties as DEHP. DEHP is a component of many household items, including tablecloths, floor tiles, shower curtains, garden hoses, rainwear, dolls, toys, shoes, medical tubing, furniture upholstery, and swimming pool liners. Common exposures come from the use of DEHP as a fragrance carrier in cosmetics , personal care products, laundry detergents , colognes, scented candles , and air fresheners.

Effects of chronic phthalate exposure on the kidney. Evaluation and analysis of exposure levels of di 2-ethylhexyl phthalate from blood bags. Hypotension and cardiac arrest in rats after infusion of mono 2-ethylhexyl phthalate MEHPdehp full form, a contaminant of stored blood.

If you have any questions, comments, or concerns about the content of this page, please contact us. Di 2-ethylhexyl phthalate DEHP. DEHP is on the Proposition 65 list because it can cause cancer and birth defects or other reproductive harm. Exposure to DEHP may increase the risk of cancer, and may also harm the male reproductive system. Exposure to DEHP during pregnancy may affect the development of the child.

Context - Diethylhexyl-phthalate DEHP is a substance that is mainly used as an additive in plastics to make them more flexible. Phthalates are widely used as additives in a wide range of plastics and other materials that are found in many consumer products. They make plastics, such as PVC, soft and flexible. As they are not chemically bound to plastics, they can be released from consumer products. There is public concern about phthalates because of their widespread use and occurrence in the environment as well as their potential effects on human health.

Dehp full form

DEHP is the most common member of the class of phthalates , which are used as plasticizers. It is the diester of phthalic acid and the branched-chain 2-ethylhexanol. This colorless viscous liquid is soluble in oil, but not in water. Di 2-ethylhexyl phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para -toluenesulfonic acid. It was first produced in commercial quantities in Japan circa and in the United States in DEHP has two stereocenters, [8] located at the carbon atoms carrying the ethyl groups.

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Contents move to sidebar hide. As a library, NLM provides access to scientific literature. Microscopic observations revealed a decrease in glycogen stores, a periportal accumulation of fat, and an accumulation of lipofuscin granules [ 77 ]. Rats and mice that ate DEHP for a long period of time developed liver cancer. Reduced hippocampal dendritic spine density and BDNF expression following acute postnatal exposure to Di 2-Ethylhexyl phthalate in male long evans rats. Bibcode : ER Once metabolized into MEHP, the molecule has been shown to lengthen action potential duration and slow epicardial conduction velocity in Langendorff perfused rodent hearts. Journal of Toxicology and Environmental Health. Di 2-ethylhexyl phthalate inhibits antral follicle growth, induces atresia, and inhibits steroid hormone production in cultured mouse antral follicles. Corresponding author.

Chemical Classification: Phthalates. Summary: Di 2-ethylhexyl phthlate DEHP is a manufactured chemical that is commonly added to plastics to make them flexible. DEHP is a colorless liquid with almost no odor.

Administration of DEHP orally by gavage in rats and mice at higher doses leads to toxic effects in the testes. BMC Women's Health. Rainwear and shoes. The effects of di 2-ethylhexyl phthalate on rat liver in relation to selenium status. DEHP has also been shown, in vitro using cardiac muscle cells, to cause activation of PPAR-alpha gene, which is a key regulator in lipid metabolism and peroxisome proliferation; both of which can be involved in atherosclerosis and hyperlipidemia , which are precursors of cardiovascular disease. Do not allow babies and children to chew on plastic objects not made for that purpose. Reddy B. Huang X. Zhang W. In vitro metabolism of di 2-ethylhexyl phthalate DEHP by various tissues and cytochrome Ps of human and rat. C Y. Hannon P. The antral follicle is an ovarian reserve and an important supplier of sex steroid hormones in females, and estradiol E2 is necessary for follicle growth. Di 2-ethylhexyl phthalate DEHP.