Affy

English Dictionary.

Middle English afien, affien , from Old French afier. Start your free trial today and get unlimited access to America's largest dictionary, with:. Accessed 16 Mar. Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! See Definitions and Examples ». Cite this Entry Citation Share. Log In.

Affy

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Affymetrix is now Applied Biosystems, a brand of DNA microarray products sold by Thermo Fisher Scientific that originated with an American biotechnology research and development and manufacturing company of the same name. Stephen Fodor and his group, based on their earlier development of methods to fabricate DNA microarrays using semiconductor manufacturing techniques. In , the company's first product under the "GeneChip" Affymetrix trademark, an HIV genotyping chip was introduced, [7] and the company went public in In January , the Food and Drug Administration approved Affymetrix's postnatal blood test, CytoScan Dx Assay, looking at whole- genome correlates of congenital abnormalities and other causes of childhood developmental delay. Affymetrix, Inc.

Affy

Affymetix was a pioneer in using print technology to synthesize oligos and the microarray surface. This enabled them to print very high density microarrays that were originally more accurate and more expensive than the low density arrays. The basic paradigm is that use of multiple oligos for each gene provides a more stable estimate of gene expression. As well, the basic idea extended readily to genotyping microarrays which are still heavily used and much cheaper than genotyping by sequencing. Although newer printing technologies and sequencing are now competitive with Affymetrix microarrays for gene expression, these arrays are still frequently used, especially for model species. As well, because these microarrays provided good quality data as early as , the historical data is still useful for planning and comparison purposes.

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Middle English afien, affien , from Old French afier.

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